PPM1F [The Human Chemical-Genetic Interaction Map Project]

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======= PPM1F =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPM1F
  * **<color #00a2e8>Official Name</color>**: protein phosphatase, Mg2+/Mn2+ dependent 1F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9647|9647]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49593|P49593]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPM1F&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPM1F|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619309|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PP2C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calmodulin-dependent protein phosphatase activity|
|histone dephosphorylation|
|negative regulation of protein kinase activity by regulation of protein phosphorylation|
|negative regulation of cell-cell adhesion mediated by cadherin|
|peptidyl-serine dephosphorylation|
|peptidyl-threonine dephosphorylation|
|magnesium-dependent protein serine/threonine phosphatase activity|
|regulation of cell-cell adhesion mediated by cadherin|
|positive regulation of focal adhesion assembly|
|negative regulation of peptidyl-serine phosphorylation|
|positive regulation of adherens junction organization|
|positive regulation of cell junction assembly|
|protein tyrosine/serine/threonine phosphatase activity|
|positive regulation of cell-matrix adhesion|
|positive regulation of stress fiber assembly|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|positive regulation of actin filament bundle assembly|
|protein serine/threonine phosphatase activity|
|regulation of adherens junction organization|
|regulation of stress fiber assembly|
|regulation of cell junction assembly|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|regulation of cell-matrix adhesion|
|positive regulation of cell-substrate adhesion|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of chemotaxis|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of epithelial cell migration|
|intrinsic apoptotic signaling pathway|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of endopeptidase activity|
|negative regulation of cell-cell adhesion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|positive regulation of peptidase activity|
|positive regulation of supramolecular fiber organization|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|protein dephosphorylation|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cytoskeleton organization|
|regulation of epithelial cell migration|
|negative regulation of protein kinase activity|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of kinase activity|
|positive regulation of growth|
|regulation of actin filament organization|
|negative regulation of cell adhesion|
|negative regulation of transferase activity|
|apoptotic signaling pathway|
|dephosphorylation|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|positive regulation of proteolysis|
|histone modification|
|covalent chromatin modification|
|regulation of actin filament-based process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|regulation of endopeptidase activity|
|negative regulation of phosphorylation|
|regulation of peptidase activity|
|negative regulation of transport|
|positive regulation of cell migration|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|protein-containing complex|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of growth|
|regulation of cell adhesion|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|chromatin organization|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|regulation of cellular localization|
|apoptotic process|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|chromosome organization|
|cell death|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.444|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2987
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPM1F Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>