PPM1F
Gene Information
- Official Symbol: PPM1F
- Official Name: protein phosphatase, Mg2+/Mn2+ dependent 1F
- Aliases and Previous Symbols: N/A
- Entrez ID: 9647
- UniProt: P49593
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.
Pfam Domains GO Terms
Pfam Domains
| PP2C |
GO Terms
| calmodulin-dependent protein phosphatase activity |
| histone dephosphorylation |
| negative regulation of protein kinase activity by regulation of protein phosphorylation |
| negative regulation of cell-cell adhesion mediated by cadherin |
| peptidyl-serine dephosphorylation |
| peptidyl-threonine dephosphorylation |
| magnesium-dependent protein serine/threonine phosphatase activity |
| regulation of cell-cell adhesion mediated by cadherin |
| positive regulation of focal adhesion assembly |
| negative regulation of peptidyl-serine phosphorylation |
| positive regulation of adherens junction organization |
| positive regulation of cell junction assembly |
| protein tyrosine/serine/threonine phosphatase activity |
| positive regulation of cell-matrix adhesion |
| positive regulation of stress fiber assembly |
| regulation of focal adhesion assembly |
| regulation of cell-substrate junction assembly |
| positive regulation of actin filament bundle assembly |
| protein serine/threonine phosphatase activity |
| regulation of adherens junction organization |
| regulation of stress fiber assembly |
| regulation of cell junction assembly |
| regulation of actomyosin structure organization |
| regulation of actin filament bundle assembly |
| regulation of cell-matrix adhesion |
| positive regulation of cell-substrate adhesion |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of chemotaxis |
| regulation of peptidyl-serine phosphorylation |
| positive regulation of epithelial cell migration |
| intrinsic apoptotic signaling pathway |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of endopeptidase activity |
| negative regulation of cell-cell adhesion |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| positive regulation of peptidase activity |
| positive regulation of supramolecular fiber organization |
| regulation of cell-substrate adhesion |
| regulation of chemotaxis |
| protein dephosphorylation |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of cytoskeleton organization |
| regulation of epithelial cell migration |
| negative regulation of protein kinase activity |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of kinase activity |
| positive regulation of growth |
| regulation of actin filament organization |
| negative regulation of cell adhesion |
| negative regulation of transferase activity |
| apoptotic signaling pathway |
| dephosphorylation |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| positive regulation of proteolysis |
| histone modification |
| covalent chromatin modification |
| regulation of actin filament-based process |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| cellular response to drug |
| negative regulation of protein phosphorylation |
| regulation of endopeptidase activity |
| negative regulation of phosphorylation |
| regulation of peptidase activity |
| negative regulation of transport |
| positive regulation of cell migration |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| positive regulation of locomotion |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| protein-containing complex |
| positive regulation of response to external stimulus |
| positive regulation of organelle organization |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of growth |
| regulation of cell adhesion |
| positive regulation of cell death |
| perinuclear region of cytoplasm |
| chromatin organization |
| regulation of protein transport |
| regulation of proteolysis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| positive regulation of hydrolase activity |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of cell migration |
| regulation of kinase activity |
| regulation of cell motility |
| regulation of cellular localization |
| apoptotic process |
| regulation of cellular component biogenesis |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| response to drug |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| chromosome organization |
| cell death |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of hydrolase activity |
| regulation of organelle organization |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PRIM1 | 0.444 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2987
- Expression level (log2 read counts): 5.65
Expression Distribution
PPM1F Expression in NALM6 Cells: 5.65
