PPP1R13B

Gene Information

Official Symbol: PPP1R13B
Official Name: protein phosphatase 1 regulatory subunit 13B
Aliases and Previous Symbols: N/A
Entrez ID: 23368
UniProt: Q96KQ4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008].
UniProt Summary: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15179
Expression level (log2 read counts): 3.83

Expression Distribution

SH3 2
Ank
Ank 2
SH3 1

regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of establishment of protein localization to mitochondrion
p53 binding
regulation of mitochondrial membrane permeability
regulation of establishment of protein localization to mitochondrion
regulation of membrane permeability
positive regulation of neuron death
positive regulation of mitochondrion organization
signal transduction by p53 class mediator
positive regulation of protein localization to membrane
mitochondrial membrane organization
intrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
regulation of signal transduction by p53 class mediator
regulation of protein localization to membrane
mitochondrial transport
apoptotic signaling pathway
regulation of neuron death
positive regulation of cellular protein localization
transcription factor binding
regulation of apoptotic signaling pathway
mitochondrion organization
positive regulation of establishment of protein localization
regulation of cellular protein localization
negative regulation of cell cycle
positive regulation of organelle organization
positive regulation of apoptotic process
positive regulation of programmed cell death
perinuclear region of cytoplasm
positive regulation of cell death
regulation of establishment of protein localization
membrane organization
regulation of cellular localization
apoptotic process
positive regulation of transport