PPP1R1A

Entrez Summary: N/A
UniProt Summary: Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein serine/threonine phosphatase inhibitor activity
glycogen metabolic process
cellular glucan metabolic process
glucan metabolic process
negative regulation of phosphoprotein phosphatase activity
energy reserve metabolic process
negative regulation of protein dephosphorylation
cellular polysaccharide metabolic process
polysaccharide metabolic process
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
regulation of protein dephosphorylation
cellular carbohydrate metabolic process
regulation of phosphatase activity
regulation of dephosphorylation
energy derivation by oxidation of organic compounds
generation of precursor metabolites and energy
negative regulation of hydrolase activity
carbohydrate metabolic process
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
negative regulation of catalytic activity
oxidation-reduction process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
extracellular space
intracellular signal transduction
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process