PPP1R7 [The Human Chemical-Genetic Interaction Map Project]

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======= PPP1R7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R7
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory subunit 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5510|5510]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15435|Q15435]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602877|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of protein phosphatase 1. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enzyme regulator activity|
|protein phosphatase regulator activity|
|positive regulation of protein dephosphorylation|
|positive regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|chromosome|
|regulation of protein dephosphorylation|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.1|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.84|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.73|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.75|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.78|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.99|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 254/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|10/28|
|blood|9/28|
|bone|10/26|
|breast|15/33|
|central nervous system|24/56|
|cervix|1/4|
|colorectal|6/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|4/16|
|kidney|10/21|
|liver|10/20|
|lung|23/75|
|lymphocyte|1/16|
|ovary|12/26|
|pancreas|9/24|
|peripheral nervous system|7/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|11/22|
|urinary tract|7/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1867
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R7 Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>