PPP1R8 [The Human Chemical-Genetic Interaction Map Project]

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======= PPP1R8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R8
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory subunit 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5511|5511]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12972|Q12972]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602636|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FHA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribonuclease E activity|
|protein serine/threonine phosphatase inhibitor activity|
|production of miRNAs involved in gene silencing by miRNA|
|dsRNA processing|
|production of small RNA involved in gene silencing by RNA|
|endonuclease activity|
|gene silencing by miRNA|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|gene silencing by RNA|
|spliceosomal complex|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|regulation of protein dephosphorylation|
|gene silencing|
|RNA phosphodiester bond hydrolysis|
|mRNA binding|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|regulation of gene expression, epigenetic|
|RNA catabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|nucleobase-containing compound catabolic process|
|RNA splicing|
|nuclear speck|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|negative regulation of hydrolase activity|
|mRNA processing|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|cell population proliferation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|mRNA metabolic process|
|negative regulation of catalytic activity|
|RNA processing|
|cellular macromolecule catabolic process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|RNA binding|
|DNA binding|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.76|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.7|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.9|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.9|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.94|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.1|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.56|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.62|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.48|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 670/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|25/28|
|bone|26/26|
|breast|32/33|
|central nervous system|49/56|
|cervix|3/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|18/20|
|lung|68/75|
|lymphocyte|13/16|
|ovary|23/26|
|pancreas|23/24|
|peripheral nervous system|14/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|8/9|
|thyroid|0/2|
|upper aerodigestive|22/22|
|urinary tract|25/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1622
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R8 Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>