PPP1R8

Entrez Summary: N/A
UniProt Summary: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 670/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	26/28
blood	25/28
bone	26/26
breast	32/33
central nervous system	49/56
cervix	3/4
colorectal	17/17
esophagus	12/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	18/20
lung	68/75
lymphocyte	13/16
ovary	23/26
pancreas	23/24
peripheral nervous system	14/16
plasma cell	14/15
prostate	1/1
skin	18/24
soft tissue	8/9
thyroid	0/2
upper aerodigestive	22/22
urinary tract	25/29
uterus	5/5

Expression Distribution

ribonuclease E activity
protein serine/threonine phosphatase inhibitor activity
production of miRNAs involved in gene silencing by miRNA
dsRNA processing
production of small RNA involved in gene silencing by RNA
endonuclease activity
gene silencing by miRNA
posttranscriptional gene silencing by RNA
posttranscriptional gene silencing
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
gene silencing by RNA
spliceosomal complex
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
regulation of protein dephosphorylation
gene silencing
RNA phosphodiester bond hydrolysis
mRNA binding
regulation of phosphatase activity
regulation of dephosphorylation
regulation of gene expression, epigenetic
RNA catabolic process
nucleic acid phosphodiester bond hydrolysis
nucleobase-containing compound catabolic process
RNA splicing
nuclear speck
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
negative regulation of hydrolase activity
mRNA processing
organic cyclic compound catabolic process
posttranscriptional regulation of gene expression
cell population proliferation
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
mRNA metabolic process