PPP2CB [The Human Chemical-Genetic Interaction Map Project]

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======= PPP2CB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP2CB
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 2 catalytic subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5516|5516]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62714|P62714]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP2CB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP2CB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176916|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. {ECO:0000269|PubMed:2555176}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metallophos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of microtubule binding|
|regulation of microtubule binding|
|peptidyl-serine dephosphorylation|
|peptidyl-threonine dephosphorylation|
|protein phosphatase type 2A complex|
|response to lead ion|
|tau protein binding|
|negative regulation of Ras protein signal transduction|
|chromosome, centromeric region|
|negative regulation of small GTPase mediated signal transduction|
|apoptotic mitochondrial changes|
|protein serine/threonine phosphatase activity|
|positive regulation of protein binding|
|response to hydrogen peroxide|
|spindle pole|
|positive regulation of binding|
|protein C-terminus binding|
|response to reactive oxygen species|
|protein dephosphorylation|
|regulation of protein binding|
|regulation of Ras protein signal transduction|
|response to endoplasmic reticulum stress|
|response to antibiotic|
|dephosphorylation|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of small GTPase mediated signal transduction|
|proteasomal protein catabolic process|
|response to metal ion|
|regulation of binding|
|response to oxidative stress|
|mitochondrion organization|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|response to inorganic substance|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|cellular macromolecule catabolic process|
|apoptotic process|
|response to drug|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|cellular response to stress|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.453|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13752
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP2CB Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>