PPP2R2D

Entrez Summary: N/A
UniProt Summary: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

Screen	Score
Colchicine 0.009μM R05 exp215	-1.76
Nocodazole 0.1μM R03 exp94	1.82

exit from mitosis
peptidyl-serine dephosphorylation
protein phosphatase type 2A complex
protein phosphatase regulator activity
protein serine/threonine phosphatase activity
regulation of phosphoprotein phosphatase activity
regulation of protein dephosphorylation
mitotic nuclear division
regulation of phosphatase activity
regulation of dephosphorylation
protein dephosphorylation
mitotic cell cycle phase transition
cell cycle phase transition
nuclear division
dephosphorylation
organelle fission
cell division
mitotic cell cycle process
mitotic cell cycle
cell cycle process
regulation of hydrolase activity
cell cycle
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process