PPP3CC

Gene Information

Official Symbol: PPP3CC
Official Name: protein phosphatase 3 catalytic subunit gamma
Aliases and Previous Symbols: N/A
Entrez ID: 5533
UniProt: P48454
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13445
Expression level (log2 read counts): 4.65

Expression Distribution

calcineurin complex
calmodulin-dependent protein phosphatase activity
positive regulation of synaptic vesicle endocytosis
positive regulation of synaptic vesicle recycling
calcineurin-NFAT signaling cascade
presynaptic cytosol
calcineurin-mediated signaling
regulation of synaptic vesicle endocytosis
inositol phosphate-mediated signaling
regulation of synaptic vesicle recycling
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of establishment of protein localization to mitochondrion
regulation of mitochondrial membrane permeability
regulation of establishment of protein localization to mitochondrion
regulation of membrane permeability
positive regulation of endocytosis
regulation of synaptic vesicle cycle
positive regulation of mitochondrion organization
positive regulation of protein localization to membrane
mitochondrial membrane organization
calcium-mediated signaling
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
regulation of protein localization to membrane
calmodulin binding
regulation of endocytosis
protein dephosphorylation
mitochondrial transport
dephosphorylation
positive regulation of cellular protein localization
second-messenger-mediated signaling
glutamatergic synapse
regulation of apoptotic signaling pathway
mitochondrion organization
positive regulation of establishment of protein localization
regulation of cellular protein localization
regulation of vesicle-mediated transport