PRDX4

Entrez Summary: The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008].
UniProt Summary: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I- kappa-B-alpha phosphorylation. {ECO:0000269|PubMed:9388242}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

negative regulation of germ cell proliferation
negative regulation of male germ cell proliferation
regulation of germ cell proliferation
regulation of male germ cell proliferation
thioredoxin peroxidase activity
protein maturation by protein folding
I-kappaB phosphorylation
4-hydroxyproline metabolic process
hydrogen peroxide catabolic process
smooth endoplasmic reticulum
hydrogen peroxide metabolic process
antibiotic catabolic process
negative regulation of reproductive process
cofactor catabolic process
I-kappaB kinase/NF-kappaB signaling
cell redox homeostasis
cellular oxidant detoxification
cellular detoxification
antibiotic metabolic process
reactive oxygen species metabolic process
secretory granule lumen
ficolin-1-rich granule lumen
detoxification
male gonad development
development of primary male sexual characteristics
drug catabolic process
male sex differentiation
regulation of reproductive process
cellular modified amino acid metabolic process
gonad development
alpha-amino acid metabolic process
cellular response to toxic substance
negative regulation of multi-organism process
development of primary sexual characteristics
protein maturation
protein folding
sex differentiation
cellular amino acid metabolic process
extracellular matrix organization
response to oxidative stress