PRKAB1 [The Human Chemical-Genetic Interaction Map Project]

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======= PRKAB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRKAB1
  * **<color #00a2e8>Official Name</color>**: protein kinase AMP-activated non-catalytic subunit beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5564|5564]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y478|Q9Y478]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRKAB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRKAB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602740|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AMPKBI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|AMP-activated protein kinase activity|
|nail development|
|nucleotide-activated protein kinase complex|
|positive regulation of cold-induced thermogenesis|
|protein heterooligomerization|
|fatty acid biosynthetic process|
|regulation of cold-induced thermogenesis|
|cell cycle arrest|
|macroautophagy|
|regulation of macroautophagy|
|limb development|
|regulation of signal transduction by p53 class mediator|
|appendage development|
|monocarboxylic acid biosynthetic process|
|protein kinase activity|
|autophagy|
|process utilizing autophagic mechanism|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|regulation of autophagy|
|protein kinase binding|
|protein complex oligomerization|
|monocarboxylic acid metabolic process|
|negative regulation of cell cycle|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|regulation of cellular catabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|protein phosphorylation|
|regulation of catabolic process|
|cell cycle process|
|oxoacid metabolic process|
|organic acid metabolic process|
|regulation of cell cycle|
|lipid metabolic process|
|phosphorylation|
|cell cycle|
|protein-containing complex assembly|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.39|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.28|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.2|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.11|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.99|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.9|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.78|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.73|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.7|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.73|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.86|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.25|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|4.19|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|7.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prkaa1|PRKAA1]]|0.659|
|[[:human genes:s:strada|STRADA]]|0.614|
|[[:human genes:p:prkag1|PRKAG1]]|0.601|
|[[:human genes:s:stk11|STK11]]|0.566|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14217
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRKAB1 Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>