PRKAB1

Entrez Summary: N/A
UniProt Summary: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp499	-2.39
Golgicide-A 4μM R03 exp122	-2.28
Wortmannin 5μM R00 exp38	-2.2
I-BRD9 4μM R07 exp365	-2.11
TRAIL 50ng/ml R00 exp36	-1.99
LY2090314 0.003μM R08 exp500 no dilution day6	-1.9
CB-5083 0.4μM R08 exp468	-1.78
Wortmannin 0.5μM R00 exp37	-1.73
Mubritinib 0.2μM R01 exp48	1.7
NN-Dimethylsphingosine 2.5μM R08 exp508	1.73
MK2206 4μM R08 exp504	1.86
Mubritinib 0.2μM R02 exp65	2.25
Arsenate 40μM R06 exp264	4.19
PF-06409577 20μM R07 exp389	7.12

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AMP-activated protein kinase activity
nail development
nucleotide-activated protein kinase complex
positive regulation of cold-induced thermogenesis
protein heterooligomerization
fatty acid biosynthetic process
regulation of cold-induced thermogenesis
cell cycle arrest
macroautophagy
regulation of macroautophagy
limb development
regulation of signal transduction by p53 class mediator
appendage development
monocarboxylic acid biosynthetic process
protein kinase activity
autophagy
process utilizing autophagic mechanism
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
regulation of autophagy
protein kinase binding
protein complex oligomerization
monocarboxylic acid metabolic process
negative regulation of cell cycle
lipid biosynthetic process
small molecule biosynthetic process
regulation of cellular catabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
protein phosphorylation
regulation of catabolic process
cell cycle process
oxoacid metabolic process
organic acid metabolic process
regulation of cell cycle
lipid metabolic process
phosphorylation
cell cycle
protein-containing complex assembly