PRKCSH

Entrez Summary: This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
UniProt Summary: Regulatory subunit of glucosidase II. {ECO:0000269|PubMed:10929008}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.96
CoCl2 18μM R07 exp346	1.97
Sulforaphane 9μM R08 exp526 no dilution day6	1.97
Trimetrexate 0.03μM R08 exp535	2.4

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PRKCSH
PRKCSH-like

glucosidase II complex
N-glycan processing
phosphoprotein binding
protein kinase C binding
ion channel binding
protein folding
endoplasmic reticulum lumen
post-translational protein modification
glycoprotein metabolic process
intracellular membrane-bounded organelle
calcium ion binding
endoplasmic reticulum
carbohydrate derivative metabolic process
intracellular signal transduction