PROP1

Entrez Summary: This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011].
UniProt Summary: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hypophysis morphogenesis
diencephalon morphogenesis
somatotropin secreting cell differentiation
hypothalamus cell differentiation
forebrain morphogenesis
adenohypophysis development
hypothalamus development
brain morphogenesis
pituitary gland development
diencephalon development
dorsal/ventral pattern formation
beta-catenin binding
canonical Wnt signaling pathway
RNA polymerase II distal enhancer sequence-specific DNA binding
gland morphogenesis
limbic system development
endocrine system development
protein C-terminus binding
transcription factor complex
DNA-binding transcription repressor activity, RNA polymerase II-specific
regionalization
Wnt signaling pathway
cell-cell signaling by wnt
forebrain development
chromatin binding
gland development
cell surface receptor signaling pathway involved in cell-cell signaling
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
blood vessel development
vasculature development
cardiovascular system development
brain development
head development
negative regulation of transcription by RNA polymerase II
circulatory system development
negative regulation of apoptotic process
negative regulation of programmed cell death
animal organ morphogenesis
cell migration