PROZ
Gene Information
- Official Symbol: PROZ
- Official Name: protein Z, vitamin K dependent plasma glycoprotein
- Aliases and Previous Symbols: N/A
- Entrez ID: 8858
- UniProt: P22891
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
- UniProt Summary: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4812
- Expression level (log2 read counts): 0.52
PROZ Expression in NALM6 Cells: 0.52
