PRPF39

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Screen	Score
Vemurafenib 6.6μM R02 exp89	1.88
MS023 7μM R03 exp135	2.14

pre-mRNA 5-splice site binding
commitment complex
mRNA 5-splice site recognition
U2-type prespliceosome
U1 snRNP
mRNA splice site selection
mRNA cis splicing, via spliceosome
spliceosomal complex assembly
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
cellular protein-containing complex assembly
RNA processing
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression