PRR14L [The Human Chemical-Genetic Interaction Map Project]

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======= PRR14L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRR14L
  * **<color #00a2e8>Official Name</color>**: proline rich 14 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=253143|253143]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5THK1|Q5THK1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRR14L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRR14L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621035|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-3.17|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-3.12|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-3.08|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.39|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.18|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.98|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.9|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.89|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.81|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.78|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.74|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.79|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.83|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.83|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.84|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.85|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.96|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.97|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.05|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|2.37|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.49|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.59|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.74|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rbm38|RBM38]]|0.559|
|[[:human genes:k:kdm6a|KDM6A]]|0.465|
|[[:human genes:a:anp32a|ANP32A]]|0.421|
|[[:human genes:d:dazap1|DAZAP1]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15339
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRR14L Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>