PSME4

Gene Information

Official Symbol: PSME4
Official Name: proteasome activator subunit 4
Aliases and Previous Symbols: N/A
Entrez ID: 23198
UniProt: Q14997
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. {ECO:0000269|PubMed:12093752, ECO:0000269|PubMed:18845680, ECO:0000269|PubMed:22550082, ECO:0000269|PubMed:23706739}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4797
Expression level (log2 read counts): 7.23

Expression Distribution

Screen	Score
Mdivi-1 15μM R05 exp217	-2.49
BVD-523 15μM R02 exp67	-2.09
Rucaparib 6.5μM R08 exp520	-2.02
Amiloride 100μM R08 exp447	1.85

spermatoproteasome complex
spermatogenesis, exchange of chromosomal proteins
peptidase activator activity
sperm chromatin condensation
proteasome binding
lysine-acetylated histone binding
spermatid nucleus differentiation
proteasomal ubiquitin-independent protein catabolic process
histone exchange
regulation of cellular amino acid metabolic process
regulation of hematopoietic stem cell differentiation
ATP-dependent chromatin remodeling
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of transcription from RNA polymerase II promoter in response to hypoxia
antigen processing and presentation of exogenous peptide antigen via MHC class I
regulation of cellular amine metabolic process
NIK/NF-kappaB signaling
anaphase-promoting complex-dependent catabolic process
regulation of hematopoietic progenitor cell differentiation
negative regulation of G2/M transition of mitotic cell cycle
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
interleukin-1-mediated signaling pathway
Wnt signaling pathway, planar cell polarity pathway
antigen processing and presentation of peptide antigen via MHC class I
negative regulation of cell cycle G2/M phase transition
regulation of establishment of planar polarity
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
regulation of stem cell differentiation
tumor necrosis factor-mediated signaling pathway
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
nucleus organization
non-canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
spermatid development
spermatid differentiation
nucleosome organization
chromatin remodeling
regulation of cellular ketone metabolic process