PTGER1

Gene Information

Official Symbol: PTGER1
Official Name: prostaglandin E receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 5731
UniProt: P34995
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5857
Expression level (log2 read counts): -6.6

Expression Distribution

negative regulation of gastric emptying
regulation of gastric emptying
prostaglandin E receptor activity
regulation of gastric motility
D1 dopamine receptor binding
adenylate cyclase-activating dopamine receptor signaling pathway
negative regulation of digestive system process
dopamine receptor signaling pathway
regulation of digestive system process
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
cellular response to catecholamine stimulus
cellular response to monoamine stimulus
response to catecholamine
response to monoamine
adenylate cyclase-activating G protein-coupled receptor signaling pathway
cellular response to ammonium ion
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
response to ammonium ion
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
response to lipopolysaccharide
response to molecule of bacterial origin
regulation of cytosolic calcium ion concentration
second-messenger-mediated signaling
cellular response to drug
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
inflammatory response
cellular response to organic cyclic compound
cellular metal ion homeostasis
regulation of system process
cellular response to organonitrogen compound
metal ion homeostasis
cellular cation homeostasis