PTGER2

Entrez Summary: This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009].
UniProt Summary: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

7TM GPCR Srx
7tm 1

positive regulation of gastric mucosal blood circulation
regulation of gastric mucosal blood circulation
prostaglandin E receptor activity
cellular response to prostaglandin E stimulus
cellular response to prostaglandin stimulus
response to prostaglandin E
response to prostaglandin
response to progesterone
cellular response to fatty acid
positive regulation of blood circulation
response to fatty acid
cellular response to alcohol
cellular response to ketone
adenylate cyclase-activating G protein-coupled receptor signaling pathway
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
response to ketone
cellular response to acid chemical
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
response to alcohol
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
regulation of blood circulation
response to lipopolysaccharide
response to molecule of bacterial origin
regulation of cytosolic calcium ion concentration
response to steroid hormone
second-messenger-mediated signaling
response to acid chemical
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
inflammatory response
cellular response to lipid
cellular metal ion homeostasis
regulation of system process
cellular response to hormone stimulus
metal ion homeostasis
cellular cation homeostasis