PTGER4

Gene Information

Official Symbol: PTGER4
Official Name: prostaglandin E receptor 4
Aliases and Previous Symbols: N/A
Entrez ID: 5734
UniProt: P35408
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3496
Expression level (log2 read counts): 2.49

Expression Distribution

7tm 1
7TM GPCR Srx

regulation of eosinophil extravasation
negative regulation of eosinophil extravasation
negative regulation of eosinophil migration
negative regulation of integrin activation
regulation of eosinophil migration
prostaglandin E receptor activity
negative regulation of cellular extravasation
regulation of integrin activation
cellular response to prostaglandin E stimulus
cellular response to prostaglandin stimulus
response to prostaglandin E
T-helper cell differentiation
CD4-positive, alpha-beta T cell differentiation involved in immune response
alpha-beta T cell differentiation involved in immune response
ERK1 and ERK2 cascade
alpha-beta T cell activation involved in immune response
regulation of cellular extravasation
response to prostaglandin
T cell differentiation involved in immune response
CD4-positive, alpha-beta T cell differentiation
CD4-positive, alpha-beta T cell activation
negative regulation of leukocyte migration
alpha-beta T cell differentiation
cellular response to fatty acid
alpha-beta T cell activation
T cell activation involved in immune response
negative regulation of cytokine secretion
regulation of stress fiber assembly
cellular response to mechanical stimulus
JNK cascade
cellular response to alcohol
response to fatty acid
regulation of actomyosin structure organization
cellular response to ketone
regulation of actin filament bundle assembly
stress-activated MAPK cascade
lymphocyte activation involved in immune response
adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of protein complex assembly
negative regulation of protein secretion