PTGES

Entrez Summary: N/A
UniProt Summary: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). {ECO:0000269|PubMed:18682561}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

prostaglandin-E synthase activity
nuclear envelope lumen
chronic inflammatory response
glutathione binding
cyclooxygenase pathway
prostaglandin biosynthetic process
prostanoid biosynthetic process
glutathione transferase activity
prostaglandin metabolic process
prostanoid metabolic process
unsaturated fatty acid biosynthetic process
icosanoid biosynthetic process
glutathione metabolic process
arachidonic acid metabolic process
acute inflammatory response
fatty acid derivative biosynthetic process
unsaturated fatty acid metabolic process
response to retinoic acid
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
response to calcium ion
fatty acid derivative metabolic process
monocarboxylic acid biosynthetic process
cellular modified amino acid metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
response to lipopolysaccharide
fatty acid metabolic process
response to molecule of bacterial origin
response to acid chemical
sulfur compound metabolic process
response to metal ion
cofactor metabolic process
inflammatory response
peptide metabolic process
monocarboxylic acid metabolic process
response to inorganic substance
lipid biosynthetic process
small molecule biosynthetic process