PTGIS

Gene Information

Official Symbol: PTGIS
Official Name: prostaglandin I2 synthase
Aliases and Previous Symbols: N/A
Entrez ID: 5740
UniProt: Q16647
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). {ECO:0000269|PubMed:18032380, ECO:0000269|PubMed:25623425}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8030
Expression level (log2 read counts): 2.89

Expression Distribution

Screen	Score
Rotenone 20μM R00 exp34	-1.88
Hydroxychloroquine 30μM R08 exp490	2.24

prostaglandin-I synthase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
positive regulation of peroxisome proliferator activated receptor signaling pathway
cyclooxygenase pathway
negative regulation of nitric oxide biosynthetic process
regulation of peroxisome proliferator activated receptor signaling pathway
NAD biosynthesis via nicotinamide riboside salvage pathway
negative regulation of nitric oxide metabolic process
positive regulation of execution phase of apoptosis
prostaglandin biosynthetic process
prostanoid biosynthetic process
decidualization
negative regulation of reactive oxygen species biosynthetic process
NAD biosynthetic process
monooxygenase activity
cellular response to interleukin-6
pyridine nucleotide biosynthetic process
nicotinamide nucleotide biosynthetic process
pyridine nucleotide metabolic process
nicotinamide nucleotide metabolic process
prostaglandin metabolic process
prostanoid metabolic process
maternal placenta development
response to interleukin-6
pyridine-containing compound biosynthetic process
embryo implantation
regulation of execution phase of apoptosis
pyridine-containing compound metabolic process
unsaturated fatty acid biosynthetic process
icosanoid biosynthetic process
oxidoreduction coenzyme metabolic process
negative regulation of reactive oxygen species metabolic process
regulation of nitric oxide biosynthetic process
arachidonic acid metabolic process
maternal process involved in female pregnancy
caveola
negative regulation of NF-kappaB transcription factor activity
regulation of reactive oxygen species biosynthetic process
fatty acid derivative biosynthetic process
unsaturated fatty acid metabolic process