PTGR1

Entrez Summary: N/A
UniProt Summary: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

2-alkenal reductase [NAD(P)] activity
15-oxoprostaglandin 13-oxidase activity
13-prostaglandin reductase activity
leukotriene metabolic process
prostaglandin metabolic process
prostanoid metabolic process
response to antineoplastic agent
unsaturated fatty acid metabolic process
icosanoid metabolic process
fatty acid derivative metabolic process
fatty acid metabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
response to drug
organic acid metabolic process
lipid metabolic process
small molecule metabolic process