PTH1R

Entrez Summary: The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010].
UniProt Summary: Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:27160269, ECO:0000269|PubMed:8397094}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

HRM
7tm 2

parathyroid hormone receptor activity
positive regulation of inositol phosphate biosynthetic process
regulation of inositol phosphate biosynthetic process
osteoblast development
bone resorption
positive regulation of alcohol biosynthetic process
G protein-coupled peptide receptor activity
peptide hormone binding
bone remodeling
bone mineralization
brush border membrane
protein self-association
positive regulation of cellular carbohydrate metabolic process
regulation of alcohol biosynthetic process
positive regulation of carbohydrate metabolic process
chondrocyte differentiation
biomineralization
biomineral tissue development
regulation of carbohydrate biosynthetic process
phospholipase C-activating G protein-coupled receptor signaling pathway
tissue remodeling
osteoblast differentiation
adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of small molecule metabolic process
regulation of cellular carbohydrate metabolic process
cAMP-mediated signaling
cell maturation
cartilage development
cyclic-nucleotide-mediated signaling
tissue homeostasis
basolateral plasma membrane
regulation of carbohydrate metabolic process
receptor complex
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
connective tissue development
developmental maturation
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
ossification
aging
positive regulation of cytosolic calcium ion concentration