PTK7
Gene Information
- Official Symbol: PTK7
- Official Name: protein tyrosine kinase 7 (inactive)
- Aliases and Previous Symbols: N/A
- Entrez ID: 5754
- UniProt: Q13308
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| I-set |
| Pkinase |
| Pkinase Tyr |
| ig |
GO Terms
| coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway |
| lung-associated mesenchyme development |
| planar cell polarity pathway involved in neural tube closure |
| convergent extension |
| regulation of establishment of planar polarity involved in neural tube closure |
| establishment of epithelial cell apical/basal polarity |
| regulation of epithelial tube formation |
| polarized epithelial cell differentiation |
| establishment of apical/basal cell polarity |
| establishment of monopolar cell polarity |
| establishment or maintenance of monopolar cell polarity |
| establishment of planar polarity |
| establishment of tissue polarity |
| cochlea morphogenesis |
| axis elongation |
| establishment of epithelial cell polarity |
| morphogenesis of a polarized epithelium |
| coronary vasculature development |
| establishment or maintenance of epithelial cell apical/basal polarity |
| establishment or maintenance of apical/basal cell polarity |
| establishment or maintenance of bipolar cell polarity |
| cochlea development |
| actin cytoskeleton reorganization |
| cellular response to retinoic acid |
| ventricular septum development |
| neural tube closure |
| tube closure |
| Wnt signaling pathway, planar cell polarity pathway |
| inner ear morphogenesis |
| primary neural tube formation |
| neural tube formation |
| response to retinoic acid |
| cardiac septum development |
| regulation of establishment of planar polarity |
| developmental growth involved in morphogenesis |
| ear morphogenesis |
| establishment of cell polarity |
| embryonic epithelial tube formation |
| cardiac ventricle development |
| regulation of embryonic development |
| epithelial tube formation |
| non-canonical Wnt signaling pathway |
| positive regulation of canonical Wnt signaling pathway |
| morphogenesis of embryonic epithelium |
| tube formation |
| neural tube development |
| lung development |
| cardiac chamber development |
| cell-cell junction |
| respiratory tube development |
| positive regulation of Wnt signaling pathway |
| regulation of morphogenesis of an epithelium |
| inner ear development |
| respiratory system development |
| establishment or maintenance of cell polarity |
| cellular response to acid chemical |
| ear development |
| mesenchyme development |
| protein kinase activity |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| positive regulation of neuron projection development |
| regulation of canonical Wnt signaling pathway |
| embryonic organ morphogenesis |
| epithelial tube morphogenesis |
| response to acid chemical |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| regulation of Wnt signaling pathway |
| positive regulation of neuron differentiation |
| positive regulation of cell projection organization |
| developmental growth |
| growth |
| focal adhesion |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| morphogenesis of an epithelium |
| embryonic organ development |
| positive regulation of neurogenesis |
| wound healing |
| blood vessel development |
| actin cytoskeleton organization |
| regulation of neuron projection development |
| vasculature development |
| cardiovascular system development |
| cellular response to lipid |
| heart development |
| positive regulation of nervous system development |
| positive regulation of cell development |
| sensory organ development |
| tissue morphogenesis |
| embryonic morphogenesis |
| actin filament-based process |
| response to wounding |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| epithelial cell differentiation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| regulation of neurogenesis |
| tube development |
| response to lipid |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| animal organ morphogenesis |
| cell migration |
| positive regulation of cell differentiation |
| protein phosphorylation |
| embryo development |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| cytoskeleton organization |
| epithelium development |
| cell-cell signaling |
| positive regulation of cellular component organization |
| phosphorylation |
| locomotion |
| positive regulation of developmental process |
| integral component of plasma membrane |
| ATP binding |
| generation of neurons |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| neurogenesis |
| positive regulation of signal transduction |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12418
- Expression level (log2 read counts): 6.86
Expression Distribution
PTK7 Expression in NALM6 Cells: 6.86
