PTPN12

Entrez Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of platelet-derived growth factor receptor-beta signaling pathway
regulation of platelet-derived growth factor receptor-beta signaling pathway
non-membrane spanning protein tyrosine phosphatase activity
negative regulation of platelet-derived growth factor receptor signaling pathway
regulation of platelet-derived growth factor receptor signaling pathway
podosome
ERBB2 signaling pathway
phosphoprotein phosphatase activity
cellular response to epidermal growth factor stimulus
response to epidermal growth factor
negative regulation of ERBB signaling pathway
tissue regeneration
ERBB signaling pathway
regulation of epidermal growth factor receptor signaling pathway
regulation of ERBB signaling pathway
cell projection
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
SH3 domain binding
regeneration
protein dephosphorylation
dephosphorylation
developmental growth
growth
focal adhesion
wound healing
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
response to wounding
enzyme linked receptor protein signaling pathway
cellular response to cytokine stimulus
response to cytokine
cellular response to endogenous stimulus
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
response to endogenous stimulus
negative regulation of response to stimulus
tissue development