PTPN13 [The Human Chemical-Genetic Interaction Map Project]

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======= PTPN13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPN13
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase non-receptor type 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5783|5783]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12923|Q12923]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPN13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPN13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600267|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FERM N|
|Y phosphatase|
|FERM M|
|PDZ|
|FERM C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol 3-kinase regulatory subunit binding|
|cell body|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|phosphatidylinositol biosynthetic process|
|regulation of phosphatidylinositol 3-kinase signaling|
|phosphatidylinositol metabolic process|
|lamellipodium|
|glycerophospholipid biosynthetic process|
|protein dephosphorylation|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|dephosphorylation|
|neuron projection|
|cytoskeleton|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|organophosphate biosynthetic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|lipid biosynthetic process|
|negative regulation of protein modification process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|lipid metabolic process|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.7|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.74|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.75|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.77|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.88|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.9|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.92|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12310
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPN13 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>