PTPN13

Entrez Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lenalidomide 20μM R07 exp375	1.7
Benzoate 20000μM R08 exp456	1.74
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.75
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.77
THZ531 0.11 to 0.125μM on day4 R07 exp410	1.88
A-196 10μM R03 exp114	1.9
GSK626616 14μM R08 exp485	1.92
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.93

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylinositol 3-kinase regulatory subunit binding
cell body
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
phosphatidylinositol biosynthetic process
regulation of phosphatidylinositol 3-kinase signaling
phosphatidylinositol metabolic process
lamellipodium
glycerophospholipid biosynthetic process
protein dephosphorylation
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
dephosphorylation
neuron projection
cytoskeleton
phospholipid metabolic process
glycerolipid metabolic process
negative regulation of protein phosphorylation
negative regulation of phosphorylation
organophosphate biosynthetic process
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
lipid biosynthetic process
negative regulation of protein modification process
organophosphate metabolic process
cellular lipid metabolic process
cellular response to cytokine stimulus
negative regulation of cellular protein metabolic process
response to cytokine
negative regulation of protein metabolic process
lipid metabolic process
regulation of protein phosphorylation
regulation of phosphorylation
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of intracellular signal transduction
regulation of protein modification process