PTPN18

Entrez Summary: N/A
UniProt Summary: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

non-membrane spanning protein tyrosine phosphatase activity
ERBB2 signaling pathway
blastocyst formation
negative regulation of ERBB signaling pathway
ERBB signaling pathway
regulation of ERBB signaling pathway
blastocyst development
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
protein dephosphorylation
dephosphorylation
in utero embryonic development
transmembrane receptor protein tyrosine kinase signaling pathway
chordate embryonic development
embryo development ending in birth or egg hatching
enzyme linked receptor protein signaling pathway
anatomical structure formation involved in morphogenesis
embryo development
cellular response to cytokine stimulus
response to cytokine
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus