PTPN3

Entrez Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
UniProt Summary: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Tunicamycin 0.04μM R07 exp418	-1.9
ABT-702 5μM R06 exp261	1.71

regulation of membrane depolarization during action potential
negative regulation of membrane protein ectodomain proteolysis
regulation of membrane protein ectodomain proteolysis
liver regeneration
sodium channel regulator activity
phosphotyrosine residue binding
regulation of membrane depolarization
negative regulation of epidermal growth factor receptor signaling pathway
regulation of action potential
negative regulation of ERBB signaling pathway
cytoplasmic side of plasma membrane
regulation of sodium ion transmembrane transporter activity
regulation of sodium ion transmembrane transport
animal organ regeneration
cytoskeletal protein binding
ATPase binding
regulation of epidermal growth factor receptor signaling pathway
regulation of sodium ion transport
regulation of ERBB signaling pathway
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
liver development
hepaticobiliary system development
negative regulation of protein catabolic process
regeneration
protein dephosphorylation
negative regulation of cellular catabolic process
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
negative regulation of mitotic cell cycle
dephosphorylation
negative regulation of catabolic process
regulation of cation transmembrane transport
negative regulation of proteolysis
cytoskeleton
regulation of protein catabolic process
regulation of metal ion transport
gland development
regulation of membrane potential