PTPRZ1

Entrez Summary: This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011].
UniProt Summary: Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

perineuronal net
regulation of oligodendrocyte progenitor proliferation
transmembrane receptor protein tyrosine phosphatase activity
positive regulation of oligodendrocyte differentiation
intrinsic component of plasma membrane
regulation of oligodendrocyte differentiation
regulation of myelination
positive regulation of glial cell differentiation
oligodendrocyte differentiation
regulation of glial cell differentiation
positive regulation of gliogenesis
hematopoietic progenitor cell differentiation
regulation of neural precursor cell proliferation
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
regulation of gliogenesis
integrin binding
negative regulation of neuron apoptotic process
glial cell differentiation
negative regulation of neuron death
regulation of neuron apoptotic process
protein dephosphorylation
gliogenesis
learning or memory
synapse
cognition
dephosphorylation
regulation of neuron death
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
positive regulation of neurogenesis
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
positive regulation of nervous system development
positive regulation of cell development
cell morphogenesis involved in differentiation
hemopoiesis