PTTG1

Entrez Summary: N/A
UniProt Summary: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11238996, ECO:0000269|PubMed:11371342, ECO:0000269|PubMed:12355087}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of mitotic sister chromatid separation
negative regulation of chromosome separation
negative regulation of mitotic sister chromatid segregation
negative regulation of sister chromatid segregation
negative regulation of chromosome segregation
cysteine-type endopeptidase inhibitor activity
negative regulation of mitotic nuclear division
negative regulation of nuclear division
homologous chromosome segregation
regulation of mitotic sister chromatid separation
regulation of chromosome separation
regulation of mitotic sister chromatid segregation
regulation of sister chromatid segregation
anaphase-promoting complex-dependent catabolic process
meiotic chromosome segregation
regulation of chromosome segregation
meiosis I
meiosis I cell cycle process
SH3 domain binding
negative regulation of chromosome organization
meiotic nuclear division
meiotic cell cycle process
regulation of mitotic nuclear division
regulation of nuclear division
nuclear chromosome segregation
meiotic cell cycle
negative regulation of endopeptidase activity
negative regulation of peptidase activity
chromosome segregation
nuclear division
negative regulation of mitotic cell cycle
organelle fission
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of cell cycle process
regulation of chromosome organization
proteasomal protein catabolic process
negative regulation of proteolysis
negative regulation of organelle organization
regulation of endopeptidase activity
regulation of peptidase activity