PWP1 [The Human Chemical-Genetic Interaction Map Project]

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======= PWP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PWP1
  * **<color #00a2e8>Official Name</color>**: PWP1 homolog, endonuclein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11137|11137]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13610|Q13610]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PWP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PWP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620055|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play an important role in cell growth and/or transcription.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|H4K20me3 modified histone binding|
|negative regulation of peptidyl-serine phosphorylation of STAT protein|
|histone H4-K20 trimethylation|
|histone H4-K20 methylation|
|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|positive regulation of stem cell differentiation|
|positive regulation of transcription by RNA polymerase I|
|regulation of peptidyl-serine phosphorylation of STAT protein|
|negative regulation of peptidyl-serine phosphorylation|
|peptidyl-lysine trimethylation|
|regulation of transcription by RNA polymerase I|
|histone lysine methylation|
|peptidyl-lysine methylation|
|histone methylation|
|regulation of stem cell differentiation|
|chromosome|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|protein methylation|
|protein alkylation|
|regulation of peptidyl-serine phosphorylation|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|ribonucleoprotein complex biogenesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|nucleolus|
|peptidyl-amino acid modification|
|positive regulation of cell differentiation|
|Golgi apparatus|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 208/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|7/28|
|blood|3/28|
|bone|4/26|
|breast|6/33|
|central nervous system|29/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|5/16|
|kidney|13/21|
|liver|4/20|
|lung|20/75|
|lymphocyte|6/16|
|ovary|4/26|
|pancreas|4/24|
|peripheral nervous system|4/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|5/22|
|urinary tract|7/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 825
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PWP1 Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>