PWP1
Gene Information
- Official Symbol: PWP1
- Official Name: PWP1 homolog, endonuclein
- Aliases and Previous Symbols: N/A
- Entrez ID: 11137
- UniProt: Q13610
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play an important role in cell growth and/or transcription.
Pfam Domains GO Terms
Pfam Domains
| WD40 |
GO Terms
| H4K20me3 modified histone binding |
| negative regulation of peptidyl-serine phosphorylation of STAT protein |
| histone H4-K20 trimethylation |
| histone H4-K20 methylation |
| positive regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| positive regulation of stem cell differentiation |
| positive regulation of transcription by RNA polymerase I |
| regulation of peptidyl-serine phosphorylation of STAT protein |
| negative regulation of peptidyl-serine phosphorylation |
| peptidyl-lysine trimethylation |
| regulation of transcription by RNA polymerase I |
| histone lysine methylation |
| peptidyl-lysine methylation |
| histone methylation |
| regulation of stem cell differentiation |
| chromosome |
| regulation of receptor signaling pathway via JAK-STAT |
| regulation of receptor signaling pathway via STAT |
| protein methylation |
| protein alkylation |
| regulation of peptidyl-serine phosphorylation |
| macromolecule methylation |
| ribosome biogenesis |
| methylation |
| peptidyl-lysine modification |
| histone modification |
| covalent chromatin modification |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| ribonucleoprotein complex biogenesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| chromatin organization |
| nucleolus |
| peptidyl-amino acid modification |
| positive regulation of cell differentiation |
| Golgi apparatus |
| negative regulation of cellular protein metabolic process |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| A-769662 20μM R07 exp331 | 1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 208/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 7/28 |
| blood | 3/28 |
| bone | 4/26 |
| breast | 6/33 |
| central nervous system | 29/56 |
| cervix | 1/4 |
| colorectal | 5/17 |
| esophagus | 3/13 |
| fibroblast | 1/1 |
| gastric | 5/16 |
| kidney | 13/21 |
| liver | 4/20 |
| lung | 20/75 |
| lymphocyte | 6/16 |
| ovary | 4/26 |
| pancreas | 4/24 |
| peripheral nervous system | 4/16 |
| plasma cell | 2/15 |
| prostate | 0/1 |
| skin | 8/24 |
| soft tissue | 5/9 |
| thyroid | 1/2 |
| upper aerodigestive | 5/22 |
| urinary tract | 7/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 825
- Expression level (log2 read counts): 6.24
Expression Distribution
PWP1 Expression in NALM6 Cells: 6.24
