PYCR1

Gene Information

Official Symbol: PYCR1
Official Name: pyrroline-5-carboxylate reductase 1
Aliases and Previous Symbols: N/A
Entrez ID: 5831
UniProt: P32322
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
UniProt Summary: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. {ECO:0000269|PubMed:16730026, ECO:0000269|PubMed:19648921}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10344
Expression level (log2 read counts): 5.86

Expression Distribution

NAD Gly3P dh N
F420 oxidored

pyrroline-5-carboxylate reductase activity
proline biosynthetic process
L-proline biosynthetic process
proline metabolic process
negative regulation of hydrogen peroxide-induced cell death
negative regulation of response to reactive oxygen species
glutamine family amino acid biosynthetic process
negative regulation of cellular response to drug
regulation of hydrogen peroxide-induced cell death
negative regulation of response to drug
regulation of response to reactive oxygen species
regulation of cellular response to drug
negative regulation of oxidative stress-induced cell death
negative regulation of cellular response to oxidative stress
negative regulation of response to oxidative stress
regulation of oxidative stress-induced cell death
alpha-amino acid biosynthetic process
glutamine family amino acid metabolic process
regulation of mitochondrial membrane potential
regulation of cellular response to oxidative stress
cellular amino acid biosynthetic process
regulation of response to oxidative stress
regulation of response to drug
alpha-amino acid metabolic process
cellular response to oxidative stress
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
mitochondrial matrix
response to oxidative stress
regulation of membrane potential
drug metabolic process
small molecule biosynthetic process
regulation of cellular response to stress
carboxylic acid metabolic process
oxidation-reduction process
negative regulation of cell death
oxoacid metabolic process
organic acid metabolic process
identical protein binding