PYDC1

Gene Information

Official Symbol: PYDC1
Official Name: pyrin domain containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 260434
UniProt: Q8WXC3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. {ECO:0000269|PubMed:12656673, ECO:0000269|PubMed:24871464}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11983
Expression level (log2 read counts): -4.6

Expression Distribution

negative regulation of NLRP3 inflammasome complex assembly
IkappaB kinase complex
regulation of NLRP3 inflammasome complex assembly
negative regulation of interleukin-1 beta secretion
negative regulation of interleukin-1 secretion
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of interleukin-1 beta production
positive regulation of interleukin-1 beta secretion
negative regulation of interleukin-1 production
positive regulation of interleukin-1 secretion
regulation of interleukin-1 beta secretion
positive regulation of interleukin-1 beta production
regulation of interleukin-1 secretion
positive regulation of interleukin-1 production
regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
negative regulation of cytokine secretion
regulation of interleukin-1 beta production
negative regulation of NF-kappaB transcription factor activity
cysteine-type endopeptidase activity
regulation of interleukin-1 production
tumor necrosis factor-mediated signaling pathway
negative regulation of protein complex assembly
negative regulation of protein secretion
negative regulation of peptide secretion
positive regulation of cytokine secretion
negative regulation of DNA-binding transcription factor activity
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
negative regulation of protein transport
negative regulation of establishment of protein localization
negative regulation of secretion by cell
regulation of cytokine secretion
negative regulation of protein kinase activity
negative regulation of secretion
cellular response to tumor necrosis factor
negative regulation of kinase activity
response to tumor necrosis factor
positive regulation of protein secretion