QSOX1

Entrez Summary: N/A
UniProt Summary: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor- suppressing capabilities being involved in growth regulation. {ECO:0000269|PubMed:10542195, ECO:0000269|PubMed:10708601, ECO:0000269|PubMed:12176051, ECO:0000269|PubMed:16806532, ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:18393449}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BN82002 4μM R07 exp340	-1.94
Epigallocatechin gallate 20μM R05 exp230	-1.93

Thioredoxin
Evr1 Alr

flavin-linked sulfhydryl oxidase activity
protein disulfide isomerase activity
extracellular matrix assembly
negative regulation of macroautophagy
FAD binding
tertiary granule lumen
intercellular bridge
specific granule lumen
integral component of Golgi membrane
platelet alpha granule lumen
cell redox homeostasis
negative regulation of autophagy
platelet degranulation
regulation of macroautophagy
negative regulation of cellular catabolic process
endoplasmic reticulum lumen
negative regulation of catabolic process
regulation of autophagy
extracellular matrix organization
post-translational protein modification
extracellular structure organization
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
Golgi membrane
leukocyte activation involved in immune response
cell activation involved in immune response
intracellular membrane-bounded organelle
regulated exocytosis
leukocyte mediated immunity
exocytosis
regulation of cellular catabolic process
cellular homeostasis
leukocyte activation