RAB7L1

Entrez Summary: N/A
UniProt Summary: Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans- Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. {ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

symbiont-containing vacuole
multi-organism toxin transport
regulation of retrograde transport, endosome to Golgi
intracellular vesicle
protein localization to ciliary membrane
viral RNA genome replication
vacuole
positive regulation of T cell receptor signaling pathway
positive regulation of receptor recycling
dynein complex binding
positive regulation of antigen receptor-mediated signaling pathway
regulation of cytoplasmic transport
regulation of receptor recycling
viral genome replication
regulation of T cell receptor signaling pathway
toxin transport
kinesin binding
protein localization to cilium
regulation of antigen receptor-mediated signaling pathway
cis-Golgi network
multi-organism transport
multi-organism localization
Rab protein signal transduction
GDP binding
retrograde transport, endosome to Golgi
synapse assembly
melanosome
recycling endosome
Golgi organization
cytosolic transport
Rab GTPase binding
positive regulation of intracellular protein transport
negative regulation of neuron projection development
trans-Golgi network
negative regulation of cell projection organization
viral life cycle
positive regulation of intracellular transport
endoplasmic reticulum to Golgi vesicle-mediated transport
negative regulation of neuron differentiation
protein localization to cell periphery