RAD17 [The Human Chemical-Genetic Interaction Map Project]

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======= RAD17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAD17
  * **<color #00a2e8>Official Name</color>**: RAD17 checkpoint clamp loader component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5884|5884]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75943|O75943]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAD17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAD17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603139|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rad17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rad17 RFC-like complex|
|DNA clamp loader activity|
|mitotic DNA replication checkpoint|
|DNA replication checkpoint|
|mitotic G2/M transition checkpoint|
|negative regulation of DNA replication|
|chromosome, telomeric region|
|negative regulation of G2/M transition of mitotic cell cycle|
|negative regulation of cell cycle G2/M phase transition|
|mitotic DNA integrity checkpoint|
|regulation of DNA replication|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|mitotic cell cycle checkpoint|
|regulation of signal transduction by p53 class mediator|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|DNA replication|
|negative regulation of cell cycle phase transition|
|nuclear chromatin|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|chromatin binding|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|DNA repair|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|nucleolus|
|cell cycle process|
|regulation of cell cycle|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.91|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.9|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.8|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kpna4|KPNA4]]|0.431|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 243/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|7/28|
|bone|8/26|
|breast|17/33|
|central nervous system|11/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|13/21|
|liver|7/20|
|lung|27/75|
|lymphocyte|3/16|
|ovary|13/26|
|pancreas|3/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|13/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1343
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAD17 Expression in NALM6 Cells: 5.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>