RAD17

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 243/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	10/28
blood	7/28
bone	8/26
breast	17/33
central nervous system	11/56
cervix	1/4
colorectal	3/17
esophagus	6/13
fibroblast	0/1
gastric	7/16
kidney	13/21
liver	7/20
lung	27/75
lymphocyte	3/16
ovary	13/26
pancreas	3/24
peripheral nervous system	4/16
plasma cell	3/15
prostate	0/1
skin	9/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	7/22
urinary tract	13/29
uterus	5/5

Expression Distribution

Rad17 RFC-like complex
DNA clamp loader activity
mitotic DNA replication checkpoint
DNA replication checkpoint
mitotic G2/M transition checkpoint
negative regulation of DNA replication
chromosome, telomeric region
negative regulation of G2/M transition of mitotic cell cycle
negative regulation of cell cycle G2/M phase transition
mitotic DNA integrity checkpoint
regulation of DNA replication
DNA damage checkpoint
DNA integrity checkpoint
mitotic cell cycle checkpoint
regulation of signal transduction by p53 class mediator
cell cycle checkpoint
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
negative regulation of mitotic cell cycle phase transition
DNA replication
negative regulation of cell cycle phase transition
nuclear chromatin
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
chromatin binding
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
DNA repair
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
DNA metabolic process
regulation of cell cycle process
cellular response to DNA damage stimulus
nucleolus
cell cycle process
regulation of cell cycle
cell cycle
negative regulation of cellular macromolecule biosynthetic process