RAD23A

Gene Information

Official Symbol: RAD23A
Official Name: RAD23 homolog A, nucleotide excision repair protein
Aliases and Previous Symbols: N/A
Entrez ID: 5886
UniProt: P54725
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in vpr-dependent replication of HIV-1 in non- proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2992
Expression level (log2 read counts): 6.46

Expression Distribution

Screen	Score
MS023 7μM R03 exp135	-1.85
All-trans-Retinoic-Acid 8μM R07 exp333	1.82

UBA
ubiquitin
XPC-binding
Rad60-SLD

ubiquitin-specific protease binding
proteasome binding
polyubiquitin modification-dependent protein binding
positive regulation of viral genome replication
protein destabilization
proteasome complex
damaged DNA binding
positive regulation of viral life cycle
ubiquitin binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
kinase binding
regulation of viral genome replication
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
single-stranded DNA binding
positive regulation of viral process
nucleotide-excision repair
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of cellular protein catabolic process
regulation of viral life cycle
regulation of ubiquitin-dependent protein catabolic process
microtubule organizing center
regulation of proteasomal protein catabolic process
regulation of viral process
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
regulation of symbiosis, encompassing mutualism through parasitism
regulation of cellular protein catabolic process
protein deubiquitination
regulation of protein stability
protein modification by small protein removal
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
positive regulation of proteolysis
positive regulation of cellular catabolic process
positive regulation of cell cycle
regulation of protein catabolic process
positive regulation of catabolic process
positive regulation of multi-organism process