RAD51AP1

Entrez Summary: N/A
UniProt Summary: May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA. {ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:9396801}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of double-strand break repair via homologous recombination
interstrand cross-link repair
cellular response to ionizing radiation
regulation of double-strand break repair
double-strand break repair via homologous recombination
recombinational repair
double-stranded DNA binding
regulation of DNA recombination
single-stranded DNA binding
regulation of DNA repair
response to ionizing radiation
cellular response to radiation
double-strand break repair
regulation of response to DNA damage stimulus
DNA recombination
nuclear chromatin
cellular response to abiotic stimulus
cellular response to environmental stimulus
regulation of DNA metabolic process
response to radiation
DNA repair
protein-containing complex
regulation of cellular response to stress
DNA metabolic process
cellular response to DNA damage stimulus
response to abiotic stimulus
RNA binding
regulation of response to stress
cellular response to stress