RALBP1

Entrez Summary: N/A
UniProt Summary: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. {ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:7673236}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

doxorubicin transport
glycoside transport
xenobiotic detoxification by transmembrane export across the plasma membrane
xenobiotic transmembrane transporter activity
Ral GTPase binding
xenobiotic transport
organic cation transport
export across plasma membrane
ATPase-coupled transmembrane transporter activity
ammonium transport
Rac GTPase binding
transmembrane transporter activity
carbohydrate derivative transport
detoxification
organic hydroxy compound transport
GTPase activator activity
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
positive regulation of GTPase activity
regulation of GTPase activity
response to toxic substance
chemotaxis
taxis
endocytosis
import into cell
positive regulation of hydrolase activity
cation transport
ion transmembrane transport
export from cell
transmembrane transport
regulation of hydrolase activity
locomotion
ion transport
positive regulation of catalytic activity
intracellular signal transduction
positive regulation of molecular function
regulation of intracellular signal transduction
nitrogen compound transport
vesicle-mediated transport
membrane