RANBP3L

Entrez Summary: N/A
UniProt Summary: Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner. {ECO:0000250|UniProtKB:Q6PDH4, ECO:0000269|PubMed:25755279}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mesenchymal cell differentiation involved in bone development
positive regulation of myoblast differentiation
Ran GTPase binding
negative regulation of osteoblast differentiation
SMAD binding
regulation of myoblast differentiation
nuclear pore
negative regulation of ossification
regulation of osteoblast differentiation
protein export from nucleus
mesenchymal cell differentiation
nuclear export
regulation of ossification
bone development
mesenchyme development
nucleocytoplasmic transport
nuclear transport
GTPase activator activity
positive regulation of GTPase activity
regulation of GTPase activity
skeletal system development
negative regulation of cell differentiation
positive regulation of hydrolase activity
negative regulation of developmental process
positive regulation of cell differentiation
intracellular protein transport
negative regulation of multicellular organismal process
regulation of hydrolase activity
positive regulation of developmental process
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
tissue development
positive regulation of molecular function
regulation of cell differentiation