RAP1GAP2

Entrez Summary: This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
UniProt Summary: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of neuron projection development
regulation of cell size
negative regulation of cell projection organization
negative regulation of neuron differentiation
nuclear membrane
GTPase activator activity
negative regulation of neurogenesis
negative regulation of nervous system development
neuron projection
negative regulation of cell development
regulation of small GTPase mediated signal transduction
regulation of cellular component size
positive regulation of GTPase activity
regulation of GTPase activity
centrosome
regulation of neuron projection development
regulation of anatomical structure size
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
perinuclear region of cytoplasm
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
positive regulation of hydrolase activity
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
negative regulation of multicellular organismal process
regulation of hydrolase activity
positive regulation of catalytic activity
generation of neurons
neurogenesis
positive regulation of molecular function
regulation of cell differentiation
regulation of intracellular signal transduction