RAP2A [The Human Chemical-Genetic Interaction Map Project]

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======= RAP2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAP2A
  * **<color #00a2e8>Official Name</color>**: RAP2A, member of RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5911|5911]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10114|P10114]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAP2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAP2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179540|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. {ECO:0000269|PubMed:14966141, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:16246175, ECO:0000269|PubMed:16540189, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:20159449}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|GTP EFTU|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rap protein signal transduction|
|establishment of epithelial cell apical/basal polarity|
|microvillus assembly|
|microvillus organization|
|polarized epithelial cell differentiation|
|establishment of apical/basal cell polarity|
|establishment of monopolar cell polarity|
|establishment or maintenance of monopolar cell polarity|
|positive regulation of protein autophosphorylation|
|establishment of epithelial cell polarity|
|morphogenesis of a polarized epithelium|
|establishment or maintenance of epithelial cell apical/basal polarity|
|regulation of protein autophosphorylation|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|actin cytoskeleton reorganization|
|GDP binding|
|recycling endosome membrane|
|regulation of dendrite morphogenesis|
|recycling endosome|
|establishment of cell polarity|
|regulation of dendrite development|
|midbody|
|protein localization to plasma membrane|
|regulation of JNK cascade|
|establishment or maintenance of cell polarity|
|magnesium ion binding|
|protein localization to cell periphery|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|Ras protein signal transduction|
|negative regulation of cell migration|
|negative regulation of cell motility|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|small GTPase mediated signal transduction|
|negative regulation of locomotion|
|GTPase activity|
|GTP binding|
|cellular response to drug|
|morphogenesis of an epithelium|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein localization to membrane|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|tissue morphogenesis|
|actin filament-based process|
|regulation of neuron differentiation|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of neurogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|positive regulation of protein modification process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|neurogenesis|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8455
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAP2A Expression in NALM6 Cells: 5.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>