RAP2A

Entrez Summary: N/A
UniProt Summary: Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. {ECO:0000269|PubMed:14966141, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:16246175, ECO:0000269|PubMed:16540189, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:20159449}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rap protein signal transduction
establishment of epithelial cell apical/basal polarity
microvillus assembly
microvillus organization
polarized epithelial cell differentiation
establishment of apical/basal cell polarity
establishment of monopolar cell polarity
establishment or maintenance of monopolar cell polarity
positive regulation of protein autophosphorylation
establishment of epithelial cell polarity
morphogenesis of a polarized epithelium
establishment or maintenance of epithelial cell apical/basal polarity
regulation of protein autophosphorylation
establishment or maintenance of bipolar cell polarity
establishment or maintenance of apical/basal cell polarity
actin cytoskeleton reorganization
GDP binding
recycling endosome membrane
regulation of dendrite morphogenesis
recycling endosome
establishment of cell polarity
regulation of dendrite development
midbody
protein localization to plasma membrane
regulation of JNK cascade
establishment or maintenance of cell polarity
magnesium ion binding
protein localization to cell periphery
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
Ras protein signal transduction
negative regulation of cell migration
negative regulation of cell motility
regulation of cell morphogenesis involved in differentiation
negative regulation of cellular component movement
small GTPase mediated signal transduction
negative regulation of locomotion
GTPase activity
GTP binding
cellular response to drug