RASGRF1 [The Human Chemical-Genetic Interaction Map Project]

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======= RASGRF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RASGRF1
  * **<color #00a2e8>Official Name</color>**: Ras protein specific guanine nucleotide releasing factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5923|5923]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13972|Q13972]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RASGRF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RASGRF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606600|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000269|PubMed:11389730}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|RasGEF|
|RasGEF N|
|RhoGEF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutamate receptor binding|
|regulation of Rac protein signal transduction|
|Ras guanyl-nucleotide exchange factor activity|
|long-term memory|
|regulation of NMDA receptor activity|
|regulation of neuronal synaptic plasticity|
|positive regulation of Ras protein signal transduction|
|regulation of glutamate receptor signaling pathway|
|Rho guanyl-nucleotide exchange factor activity|
|positive regulation of small GTPase mediated signal transduction|
|regulation of neurotransmitter receptor activity|
|activation of GTPase activity|
|guanyl-nucleotide exchange factor activity|
|memory|
|growth cone|
|regulation of Rho protein signal transduction|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|regulation of synaptic plasticity|
|regulation of Ras protein signal transduction|
|response to endoplasmic reticulum stress|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|cognition|
|small GTPase mediated signal transduction|
|neuron projection|
|regulation of cation transmembrane transport|
|regulation of small GTPase mediated signal transduction|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|positive regulation of GTPase activity|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of ion transmembrane transport|
|regulation of GTPase activity|
|cell population proliferation|
|regulation of transmembrane transport|
|behavior|
|neuron projection development|
|regulation of ion transport|
|positive regulation of hydrolase activity|
|neuron development|
|protein phosphorylation|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of hydrolase activity|
|phosphorylation|
|nervous system process|
|positive regulation of catalytic activity|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6297
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RASGRF1 Expression in NALM6 Cells: -0.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>